Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.32 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816557 | 0.91 | GABRA1 (0.38) | NAMPTCNR1CKS1BSKP1SKP2 | |
| SCHEMBL3821995 | 0.85 | CNR1 (0.51) | CNR1CKS1BSKP1SKP2GABRA5 | |
| SCHEMBL3822661 | 0.80 | CNR1 (0.47) | CNR1GABRA5 | |
| SCHEMBL3813909 | 0.79 | CNR1 (0.40) | CNR1CKS1BSKP1SKP2 | |
| SCHEMBL3812006 | 0.78 | CNR1 (0.49) | CNR1GABRA5EPHX2 | |
| SCHEMBL3822011 | 0.77 | CNR1 (0.40) | CNR1CKS1BSKP1SKP2KDM4E | |
| SCHEMBL3820971 | 0.76 | CNR1 (0.51) | CNR1GABRA5 | |
| SCHEMBL3819129 | 0.76 | CNR1 (0.49) | CNR1 | |
| SCHEMBL3818600 | 0.73 | CNR1 (0.49) | CNR1CYP2C9KDM4E | |
| SCHEMBL4013599 | 0.71 | CNR1 (0.57) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035394-B1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | EP | claimed |