Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 2/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL15094110 | 1.00 | SLC1A5 (0.38) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL3517747 | 0.95 | SLC1A5 (0.41) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL18191257 | 0.95 | SLC1A5 (0.41) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL9702742 | 0.95 | SLC1A5 (0.41) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL12500457 | 0.94 | SLC1A5 (0.33) | SLC1A5SLC1A1GSRGRM8GRM6 | |
| Glycine SCHEMBL1548291 | 0.93 | SLC1A5 (0.38) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL7925097 | 0.92 | SLC1A5 (0.42) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL3052910 | 0.90 | SLC1A5 (0.35) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL3628164 | 0.90 | SLC1A1 (0.41) | SLC1A1GSRGRM8GRM6GRIN2D | |
| SCHEMBL12500454 | 0.90 | SLC1A5 (0.40) | SLC1A5SLC1A1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934350-B1 | POLYOLEOSINS | AGRICULTURE VICTORIA SERV PTY (AU) | 2018-04-18 | — | — | EP | disclosed |
| US-8309794-B2 | Polyoleosins | AGRICULTURE VICTORIA SERVICES PTY LTD (AU) | 2012-11-13 | — | — | US | disclosed |
| EP-1934350-A4 | POLYOLEOSINS | AGRICULTURE VICTORIA SERV PTY (AU) | 2009-08-19 | — | — | EP | disclosed |
| US-20090133160-A1 | Polyoleosins | AGRICULTURE VICTORIA SERVICES PTY LTD (AU) | 2009-05-21 | — | — | US | disclosed |
| EP-1934350-A2 | POLYOLEOSINS | Agriculture Victoria Services Pty Ltd (AU) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007045019-A2 | POLYOLEOSINS | AGRICULTURE VICTORIA SERVICES PTY LTD (AU) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090133160-A1 | Polyoleosins | DNAJC10, PUF60, NOP2 | SLC1A5 3821/4885SLC1A1 4261/4885NOS3 3662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.