Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | GSR | P00390 | 2/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL3517747 | 1.00 | SLC1A5 (0.41) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL18191257 | 1.00 | SLC1A5 (0.41) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL7925097 | 0.96 | SLC1A5 (0.42) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL15094110 | 0.95 | SLC1A5 (0.38) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL3821533 | 0.95 | SLC1A5 (0.38) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Glycine SCHEMBL8588130 | 0.93 | GLRA1 (0.42) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL9840166 | 0.91 | SLC1A5 (0.35) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL9839515 | 0.91 | SLC1A5 (0.35) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL17072285 | 0.90 | SLC1A5 (0.39) | SLC1A5SLC1A1NOS3NOS1NOS2 | |
| Serine SCHEMBL12500457 | 0.89 | SLC1A5 (0.33) | SLC1A5SLC1A1GLRA1SLC6A9OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012952-A1 | MALIC ACID DERIVATIVES AND COMPOSITIONS FOR THE TREATMENT OF PSORIASIS | DEXTER CHEMICAL CORPORATION (US) | 1992-08-06 | — | — | WO | disclosed |