SCHEMBL3821797

SCHEMBL3821797

[CH2]Cc1ccc2ccncc2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.54
TBXAS1 P24557 1/20 0.54
PRKCZ Q05513 1/20 0.46
MELK Q14680 2/20 0.45
MRGPRX4 Q96LA9 1/20 0.38
NAMPT P43490 1/20 0.37
IKBKB O14920 1/20 0.37
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
PRKCI P41743 1/20 0.36
TDO2 P48775 1/20 0.36
GSK3B P49841 1/20 0.36
IMPDH2 P12268 1/20 0.36
NOTUM Q6P988 1/20 0.36
CSNK1D P48730 1/20 0.36
CSNK1E P49674 1/20 0.36
CLK1 P49759 1/20 0.36
DYRK1A Q13627 1/20 0.36
AKT1 P31749 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3825275 0.92 CYP19A1 (0.54) CYP19A1TBXAS1PRKCZMELKIMPDH2
SCHEMBL5779124 0.80 MELK (0.55) CYP19A1TBXAS1PRKCZMELKIKBKB
SCHEMBL3153982 0.80 CYP19A1 (0.54) CYP19A1TBXAS1PRKCZMELKMRGPRX4
SCHEMBL6897234 0.80 CYP19A1 (0.54) CYP19A1TBXAS1PRKCZMELKMRGPRX4
SCHEMBL30896286 0.80 CYP19A1 (0.54) CYP19A1TBXAS1PRKCZMELKMRGPRX4
SCHEMBL6114863 0.80 CYP1A2 (0.55) CYP19A1TBXAS1PRKCZMELKMRGPRX4
SCHEMBL6042697 0.80 CYP19A1 (0.54) CYP19A1TBXAS1PRKCZMELKMRGPRX4
SCHEMBL24343240 0.79 CYP19A1 (0.50) CYP19A1TBXAS1PRKCZMELKMRGPRX4
SCHEMBL1401429 0.77 CYP19A1 (0.51) CYP19A1TBXAS1PRKCZMELKMRGPRX4
SCHEMBL29952031 0.77 CYP19A1 (0.51) CYP19A1TBXAS1PRKCZMELKMRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2091929-A1 AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS The European Molecular Biology Laboratory (DE) 2009-08-26 EP claimed
CN-101421257-A Agents that disrupt cellular replication and their use in inhibiting pathological conditions EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE) 2009-04-29 CN claimed
WO-2007107352-A1 AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS THE EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) 2007-09-27 WO claimed
CN-107820496-A For treating and preventing the hepatitis b virus infected new formic acid derivates of 4 oxo pyridine of Fourth Ring 3 豪夫迈·罗氏有限公司 2018-03-20 CN disclosed
EP-2091929-A1 AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS The European Molecular Biology Laboratory (DE) 2009-08-26 EP disclosed
WO-2007115805-A2 AURORA KINASE INHIBITORS EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) 2007-10-18 WO disclosed
WO-2007113005-A2 2-SUBSTITUTED 3-AMINOSULFONYL-THIOPHENE DERIVATIVES AS AURORA KINASE INHIBITORS EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) 2007-10-11 WO disclosed
WO-2007107352-A1 AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS THE EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) 2007-09-27 WO disclosed