Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130809 | 1.00 | HRH3 (0.35) | HRH3KMT2ADPP4AOC3KCNQ3 | |
| SCHEMBL19932538 | 0.82 | HRH3 (0.34) | HRH3 | |
| SCHEMBL13101427 | 0.82 | HRH3 (0.49) | HRH3KMT2AKCNQ3KCNQ2SIGMAR1 | |
| SCHEMBL4047010 | 0.78 | KDM4E (0.32) | HRH3DPP4 | |
| SCHEMBL31704439 | 0.77 | SIGMAR1 (0.42) | HRH3KMT2ASIGMAR1 | |
| SCHEMBL178416 | 0.76 | HRH3 (0.44) | HRH3 | |
| SCHEMBL25571546 | 0.76 | KMT2A (0.33) | HRH3KMT2AKCNQ3KCNQ2 | |
| SCHEMBL21096753 | 0.75 | — | — | |
| SCHEMBL11224155 | 0.75 | ALDH1A1 (0.37) | KMT2A | |
| SCHEMBL19462858 | 0.74 | KMT2A (0.35) | HRH3KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091927-A1 | THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-Roche AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008055840-A1 | THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |