Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058261 | 0.88 | POLB (0.46) | POLBKDM4EMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL3063300 | 0.84 | POLB (0.44) | POLBKDM4EMAPTSMN1; SMN2AOC3 | |
| SCHEMBL8195085 | 0.81 | CXCR2 (0.47) | POLBKDM4EMAPTSMN1; SMN2CTNNB1 | |
| SCHEMBL3063698 | 0.80 | POLB (0.42) | POLBKDM4EMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL3823489 | 0.80 | KDM4E (0.47) | POLBKDM4EMAPTSMN1; SMN2CTNNB1 | |
| SCHEMBL3819450 | 0.80 | CACNA1H (0.46) | KDM4EAOC3 | |
| SCHEMBL3054777 | 0.76 | POLB (0.43) | POLBKDM4EMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL3068377 | 0.75 | CYP3A4 (0.42) | POLBAOC3CYP3A4ALDH1A1 | |
| SCHEMBL3061759 | 0.74 | TRPV1 (0.41) | POLBSMN1; SMN2AOC3CXCR2CYP3A4 | |
| SCHEMBL3823150 | 0.70 | ME2 (0.42) | POLBKDM4ESMN1; SMN2AOC3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |