Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823489 | 0.92 | KDM4E (0.47) | CXCR2CTNNB1TCF7L2POLBMAPK14 | |
| SCHEMBL8180174 | 0.86 | PDK1 (0.43) | CXCR2MAPK14PDK1ALDH1A1 | |
| SCHEMBL8179569 | 0.86 | PDK1 (0.43) | CXCR2CTNNB1TCF7L2MAPK14PDK1 | |
| SCHEMBL3058261 | 0.84 | POLB (0.46) | CXCR2NPSR1CTNNB1TCF7L2POLB | |
| SCHEMBL3063300 | 0.82 | POLB (0.44) | CXCR2NPSR1CTNNB1TCF7L2POLB | |
| SCHEMBL3822248 | 0.81 | POLB (0.43) | CXCR2NPSR1CTNNB1TCF7L2POLB | |
| SCHEMBL3063698 | 0.80 | POLB (0.42) | CXCR2NPSR1CTNNB1TCF7L2POLB | |
| SCHEMBL3824063 | 0.79 | PDK1 (0.48) | NPSR1MAPK14TP53KDM4EPDK1 | |
| SCHEMBL3823781 | 0.78 | PDK1 (0.46) | CXCR2MAPK14PDK1 | |
| SCHEMBL3827716 | 0.78 | PDK1 (0.46) | CXCR2MAPK14PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |