Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.38 |
| ▸ | CCNC | P24863 | 3/20 | 0.37 |
| ▸ | CDK8 | P49336 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558505 | 0.84 | CSNK2A2 (0.35) | CSNK2A1 | |
| Hydrochloric Acid SCHEMBL6052926 | 0.83 | CSNK2A2 (0.34) | CSNK2A1 | |
| SCHEMBL29377248 | 0.83 | RPS6KB1 (0.36) | JAK2JAK1TYK2JAK3CSNK2A1 | |
| SCHEMBL1559078 | 0.83 | RPS6KB1 (0.36) | JAK2JAK1TYK2JAK3CSNK2A1 | |
| Hydrochloric Acid SCHEMBL1560043 | 0.82 | RPS6KB1 (0.35) | JAK2JAK1TYK2JAK3CSNK2A1 | |
| Phosphoric Acid SCHEMBL20600153 | 0.81 | RPS6KB1 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL382261 | 0.78 | EIF2AK4 (0.39) | YTHDC1PAK1CCNCCDK8CSNK2A1 | |
| Trifluoroacetic Acid SCHEMBL9936778 | 0.77 | L3MBTL1 (0.34) | CSNK2A1 | |
| SCHEMBL6634413 | 0.68 | YTHDC1 (0.47) | YTHDC1PAK1CCNCCDK8JAK2 | |
| SCHEMBL666445 | 0.68 | PLK1 (0.50) | FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125822-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-12-02 | — | — | EP | claimed |
| EP-1986632-A1 | COMBINATIONS COMPRISING A CDK INHIBITOR AND A GROWTH FACTOR ANTIBODY OR ANTI-MITOTIC | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-11-05 | — | — | EP | claimed |
| WO-2008074788-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-26 | — | — | WO | claimed |
| WO-2007090794-A1 | COMBINATIONS COMPRISING A CDK INHIBITOR AND A GROWTH FACTOR ANTIBODY OR ANTI-MITOTIC | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-08-16 | — | — | WO | claimed |
| EP-2408776-A1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF THYMOMA | Nerviano Medical Sciences S.r.l. (IT) | 2012-01-25 | — | — | EP | disclosed |
| EP-2323664-A1 | USE OF A CDK INHIBITOR FOR THE TREATMENT OF GLIOMA | Nerviano Medical Sciences S.r.l. (IT) | 2011-05-25 | — | — | EP | disclosed |
| EP-2320903-A1 | THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT | Nerviano Medical Sciences S.r.l. (IT) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010012733-A9 | USE OF A CDK INHIBITOR FOR THE TREATMENT OF GLIOMA | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-04-14 | — | — | WO | disclosed |
| WO-2010106028-A1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF THYMOMA | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-09-23 | — | — | WO | disclosed |
| WO-2010012777-A1 | THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-02-04 | — | — | WO | disclosed |
| WO-2010012733-A1 | USE OF A CDK INHIBITOR FOR THE TREATMENT OF GLIOMA | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-02-04 | — | — | WO | disclosed |
| EP-1636236-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004104007-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-12-02 | — | — | WO | disclosed |