Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29286131 | 0.94 | EPHX2 (0.44) | HPGDHDAC11MAPTRXFP1EPHX2 | |
| SCHEMBL1122046 | 0.94 | HDAC11 (0.46) | HPGDSMN1; SMN2HDAC3MAPK1ADRA1A | |
| SCHEMBL8747296 | 0.91 | MAPT (0.49) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL11128523 | 0.88 | MAPT (0.45) | HPGDSMN1; SMN2HDAC3MAPK1ADRA1A | |
| SCHEMBL1034999 | 0.88 | MAPT (0.45) | HPGDSMN1; SMN2HDAC3MAPK1ADRA1A | |
| SCHEMBL11128103 | 0.88 | MAPT (0.45) | HPGDSMN1; SMN2HDAC3MAPK1ADRA1A | |
| SCHEMBL7432415 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL27681244 | 0.83 | SMN1; SMN2 (0.47) | HPGDSMN1; SMN2HDAC3MAPK1ADRA1A | |
| SCHEMBL28214575 | 0.83 | MMP1 (0.47) | HPGDSMN1; SMN2HIF1AEPHX2MEN1 | |
| SCHEMBL675542 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097400-A2 | FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008082009-A2 | FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2008-07-10 | — | — | WO | disclosed |