Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.46 |
| ▸ | LCK | P06239 | 8/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830492 | 0.92 | BTK (0.46) | BTKLCKCSF1RDAPK1BMX | |
| SCHEMBL3825451 | 0.91 | BTK (0.51) | BTKLCKCSF1RDAPK1BMX | |
| SCHEMBL3829780 | 0.91 | BTK (0.47) | BTKLCKCSF1RDAPK1BMX | |
| SCHEMBL3825126 | 0.88 | BTK (0.49) | BTKLCKCSF1RDAPK1BLK | |
| SCHEMBL3825482 | 0.88 | TNK2 (0.50) | BTKLCKCSF1RDAPK1BMX | |
| SCHEMBL3825040 | 0.87 | BTK (0.49) | BTKLCKCSF1RDAPK1ABL1 | |
| SCHEMBL3828971 | 0.86 | TNK2 (0.52) | BTKLCKBMXABL1BCR | |
| SCHEMBL3830993 | 0.86 | BTK (0.49) | BTKLCKCSF1RDAPK1BMX | |
| SCHEMBL3824777 | 0.86 | MAPT (0.48) | BTKLCKCSF1RBMXABL1 | |
| SCHEMBL3830881 | 0.85 | BTK (0.49) | BTKLCKCSF1RDAPK1TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | disclosed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | disclosed |