Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 2/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 11/20 | 0.49 |
| ▸ | LCK | P06239 | 7/20 | 0.45 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825451 | 0.90 | BTK (0.51) | TNK2MAP4K2BTKLCKCSF1R | |
| SCHEMBL3825126 | 0.89 | BTK (0.49) | BTKLCKCSF1RDAPK1BLK | |
| SCHEMBL3824944 | 0.88 | BTK (0.46) | TNK2MAP4K2BTKLCKCSF1R | |
| SCHEMBL3829780 | 0.88 | BTK (0.47) | TNK2MAP4K2BTKLCKCSF1R | |
| SCHEMBL3825146 | 0.87 | BTK (0.44) | BTKLCKCSF1RDAPK1BLK | |
| SCHEMBL3825040 | 0.87 | BTK (0.49) | BTKLCKCSF1RDAPK1BLK | |
| SCHEMBL3830492 | 0.86 | BTK (0.46) | TNK2MAP4K2BTKLCKCSF1R | |
| SCHEMBL3830993 | 0.85 | BTK (0.49) | BTKLCKCSF1RDAPK1BLK | |
| SCHEMBL3824777 | 0.85 | MAPT (0.48) | TNK2MAP4K2BTKLCKCSF1R | |
| SCHEMBL3830881 | 0.85 | BTK (0.49) | TNK2MAP4K2BTKLCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | claimed |
| JP-2007500725-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | claimed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | claimed |