Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 6/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827396 | 0.90 | CFTR (0.42) | GBA1CFTRSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL5455419 | 0.89 | CFTR (0.41) | GBA1CFTRSLC6A2SLC6A4SLC6A3 | |
| Doxpicomine SCHEMBL29356901 | 0.72 | SLC6A2 (0.38) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| Doxpicomine SCHEMBL11176546 | 0.72 | SLC6A2 (0.38) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| Doxpicomine SCHEMBL122961 | 0.71 | TSHR (0.37) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| Doxpicomine SCHEMBL29658207 | 0.71 | TSHR (0.37) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL11860493 | 0.71 | TSHR (0.37) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| Doxpicomine SCHEMBL11865226 | 0.71 | TSHR (0.37) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL9568045 | 0.71 | TAOK1 (0.39) | IDO1TDO2CFTRSLC6A2SLC6A4 | |
| SCHEMBL11869198 | 0.70 | CFTR (0.40) | CFTRSLC6A2SLC6A4SLC6A3GOPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278338-B2 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | claimed |
| EP-1758860-B1 | SATURATED AND UNSATURATED 3-PYRIDYL-BENZOCYCLOALKYLMETHYL-AMINES FOR USE IN THE TREATMENT OF PAINS, DEPRESSIONS AND ANXIETY STATES | GRUENENTHAL GMBH (DE) | 2009-09-02 | — | — | EP | claimed |
| US-20070203192-A1 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH | 2007-08-30 | — | — | US | claimed |
| US-8278338-B2 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20070203192-A1 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203192-A1 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | OPRK1, OPRM1, OPRL1 | GBA1 1512/4885IDO1 970/4885TDO2 1332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.