Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243967 | 0.86 | ALDH1A1 (0.68) | ALDH1A1HPGDHTTSMN1; SMN2LMNA | |
| SCHEMBL23393437 | 0.85 | ALDH1A1 (0.40) | ALDH1A1HPGDHTTSMN1; SMN2LMNA | |
| SCHEMBL23393436 | 0.84 | ALDH1A1 (0.46) | ALDH1A1HPGDHTTSMN1; SMN2LMNA | |
| SCHEMBL28635107 | 0.84 | EGFR (0.40) | ALDH1A1HPGDHTTSMN1; SMN2LMNA | |
| SCHEMBL6048623 | 0.84 | KCNN4 (0.49) | ALDH1A1HPGDLMNACYP1A2CYP2C19 | |
| SCHEMBL23393432 | 0.81 | PTGDR2 (0.47) | ALDH1A1HPGDHTTSMN1; SMN2PTGDR2 | |
| SCHEMBL2474418 | 0.80 | ERN1 (0.57) | ALDH1A1HPGDHTTSMN1; SMN2LMNA | |
| SCHEMBL12961839 | 0.80 | SRC (0.47) | ALDH1A1HPGDHTTSMN1; SMN2LMNA | |
| SCHEMBL6240409 | 0.79 | ALDH1A1 (0.53) | ALDH1A1HPGDHTTSMN1; SMN2LMNA | |
| SCHEMBL22804095 | 0.78 | TLR2 (0.50) | ALDH1A1HPGDHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-B1 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |