Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457227 | 0.81 | OPRM1 (0.47) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL31575348 | 0.76 | CHRNB2 (0.43) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL31575359 | 0.76 | CHRNB2 (0.43) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL10112661 | 0.73 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL31575328 | 0.72 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3CHRM1CHRNB2 | |
| SCHEMBL30166180 | 0.72 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3CHRM1CHRNB2 | |
| SCHEMBL24245936 | 0.71 | CHRNB4 (0.51) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL18610254 | 0.71 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL12261486 | 0.71 | SLC6A4 (0.59) | SLC6A2SLC6A4SLC6A3CHRM1 | |
| SCHEMBL14471693 | 0.70 | CHRNB4 (0.63) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280970-B1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2014-01-08 | — | — | EP | disclosed |
| WO-2009132986-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-05 | — | — | WO | disclosed |