Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.54 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952675 | 0.92 | MET (0.54) | METCDKL5KCNH2 | |
| SCHEMBL1953334 | 0.85 | MET (0.76) | METCDKL5KCNH2 | |
| SCHEMBL3829046 | 0.84 | MET (0.66) | METCDKL5KCNH2 | |
| SCHEMBL1949989 | 0.84 | MET (0.54) | METCDKL5 | |
| SCHEMBL3827962 | 0.82 | MET (0.53) | METCDKL5 | |
| SCHEMBL1953313 | 0.82 | MET (0.74) | METCDKL5KCNH2 | |
| SCHEMBL3825985 | 0.82 | MET (0.52) | METCDKL5KCNH2 | |
| SCHEMBL14124283 | 0.82 | MET (0.73) | METCDKL5KCNH2 | |
| SCHEMBL1951919 | 0.81 | MET (0.44) | METCDKL5 | |
| SCHEMBL1954142 | 0.81 | MET (0.71) | METCDKL5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |