SCHEMBL3825965

SCHEMBL3825965

CC(=O)CCC(c1ccccc1)N1CCCCC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.58
CYP2C19 P33261 4/20 0.58
CYP2C9 P11712 3/20 0.58
HPGD P15428 1/20 0.58
MAPK1 P28482 1/20 0.58
CYP3A4 P08684 3/20 0.54
CYP2D6 P10635 3/20 0.54
TSHR P16473 1/20 0.54
GAA P10253 2/20 0.50
ALDH1A1 P00352 3/20 0.49
LMNA P02545 2/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
KCNA5 P22460 2/20 0.46
KCNH2 Q12809 2/20 0.46
KCNE1 P15382 1/20 0.46
OPRD1 P41143 3/20 0.45
OPRM1 P35372 2/20 0.45
OPRK1 P41145 2/20 0.45
OPRL1 P41146 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1667533 0.85 ALDH1A1 (0.49) CYP2C19CYP3A4TSHRALDH1A1LMNA
SCHEMBL11221313 0.80 ALDH1A1 (0.50) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL113896 0.79 CYP1A2 (0.62) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL10601133 0.79 CYP1A2 (0.62) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL492276 0.78 CYP1A2 (0.61) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL4855890 0.78 CYP1A2 (0.74) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL10598753 0.77 OPRM1 (0.63) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL10926020 0.76 ALDH1A1 (0.52) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL547997 0.76 CYP1A2 (0.49) CYP1A2CYP2C19CYP2C9HPGDMAPK1
SCHEMBL5755490 0.76 CYP1A2 (0.62) CYP1A2CYP2C19CYP2C9HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2099758-A1 ANTIBACTERIAL QUINOLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2009-09-16 EP disclosed
CN-101423502-A 1-heterocycle-5-phenyl-2amylene-1-ones compounds as well as preparation method and application thereof UNIV CHINA AGRICULTURAL (CN) 2009-05-06 CN disclosed
WO-2008068267-A1 ANTIBACTERIAL QUINOLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2008-06-12 WO disclosed
EP-1898909-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 2008-03-19 EP disclosed
WO-2007000434-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 2007-01-04 WO disclosed