Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831726 | 0.96 | RXFP1 (0.42) | CCNE1CDK2TYK2PDE4DRXFP1 | |
| SCHEMBL3833812 | 0.93 | TAF1 (0.44) | CCNE1CDK2POLBALOX15ALDH1A1 | |
| SCHEMBL3832654 | 0.93 | P2RX3 (0.41) | CCNE1CDK2TYK2PDE4DRXFP1 | |
| SCHEMBL3827686 | 0.87 | RAB9A (0.42) | CCNE1CDK2MAPTTP53POLB | |
| SCHEMBL3826198 | 0.85 | CNR1 (0.39) | ALDH1A1RET | |
| SCHEMBL3833011 | 0.84 | MAPT (0.37) | RXFP1MAPTTP53ALDH1A1RET | |
| SCHEMBL5821098 | 0.83 | MAPK1 (0.41) | RXFP1MAPTALDH1A1RET | |
| SCHEMBL3833160 | 0.83 | RET (0.38) | CCNE1CDK2RET | |
| SCHEMBL3831731 | 0.83 | NPC1 (0.46) | MAPTPOLBALDH1A1 | |
| SCHEMBL4794491 | 0.82 | RET (0.36) | RXFP1MAPTALDH1A1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089018-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008067121-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | LEXICON PHARMACEUTICALS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2006124897-A2 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITION | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | disclosed |