Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709873 | 0.86 | GRIA4 (0.46) | GRIA4 | |
| SCHEMBL20234616 | 0.84 | RIPK1 (0.47) | TAAR1PTGES2RIPK1AOC3GRIA4 | |
| SCHEMBL6749856 | 0.82 | CA1 (0.43) | GBA1ALDH1A1 | |
| SCHEMBL27911010 | 0.80 | TAAR1 (0.43) | TAAR1PTGES2RIPK1GBA1ALDH1A1 | |
| SCHEMBL27911005 | 0.80 | TAAR1 (0.43) | TAAR1PTGES2RIPK1GBA1ALDH1A1 | |
| SCHEMBL27893888 | 0.80 | TAAR1 (0.43) | TAAR1PTGES2RIPK1GBA1ALDH1A1 | |
| SCHEMBL21295131 | 0.80 | PNMT (0.47) | PTGES2 | |
| SCHEMBL30601282 | 0.77 | CA1 (0.42) | PTGES2ALDH1A1 | |
| SCHEMBL27895132 | 0.76 | TAAR1 (0.39) | TAAR1PTGES2RIPK1GBA1ALDH1A1 | |
| SCHEMBL27912297 | 0.76 | TAAR1 (0.39) | TAAR1PTGES2RIPK1GBA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102153-A1 | AMPA RECEPTOR POTENTIATORS | Eli Lilly & Company (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008073789-A1 | AMPA RECEPTOR POTENTIATORS | ELI LILLY AND COMPANY (US) | 2008-06-19 | — | — | WO | disclosed |