Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306139 | 0.87 | MAPT (0.58) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL8700270 | 0.87 | EGFR (0.48) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL6141824 | 0.85 | MAPT (0.55) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL4140392 | 0.81 | CES2 (0.52) | RAB9ANPC1ALDH1A1TP53TSHR | |
| SCHEMBL3047824 | 0.81 | ESRRG (0.56) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL3829871 | 0.80 | RAB9A (0.63) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL8695963 | 0.80 | RAB9A (0.63) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL16561453 | 0.80 | ESRRG (0.59) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL14982110 | 0.80 | RAB9A (0.63) | MAPTKMT2AMEN1NOX1MCL1 | |
| SCHEMBL3828546 | 0.80 | HPGD (0.42) | MAPTKMT2AMEN1NOX1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-B1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | TAIJI BIOMEDICAL INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2082740-A2 | Use of imidazole derivatives as MDR modulators | Taiji Biomedical, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-0999835-A4 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0999835-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | Ontogen Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002155-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |
| US-5840721-A | INCREASE SENSITIVITY OF MULTIDRUG RESISTANT TUMOR CELLS TO ANTICANCER AGENTS | ONTOGEN CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |
| US-5756527-A | ANTICARCINOGENIC AGENTS | ONTOGEN CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0812830-A1 | Modulators of multi-drug resistances | ONTOGEN CORPORATION (US) | 1997-12-17 | — | — | EP | disclosed |