Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829271 | 0.89 | ADORA3 (0.39) | MEN1KMT2AHSD17B10ALDH1A1TSHR | |
| SCHEMBL4400986 | 0.89 | ADORA3 (0.39) | MEN1KMT2AHSD17B10ALDH1A1TSHR | |
| SCHEMBL5820105 | 0.87 | KDM4E (0.36) | MEN1KMT2AHSD17B10HCAR2KDM4E | |
| SCHEMBL5819978 | 0.80 | MEN1 (0.36) | MEN1KMT2AHSD17B10ALDH1A1TSHR | |
| SCHEMBL5819975 | 0.80 | MEN1 (0.36) | MEN1KMT2AHSD17B10ALDH1A1TSHR | |
| SCHEMBL3834103 | 0.79 | RET (0.38) | MEN1KMT2AHSD17B10HCAR2KDM4E | |
| SCHEMBL3830191 | 0.77 | MAPT (0.37) | MEN1KMT2AHSD17B10ALDH1A1TSHR | |
| SCHEMBL3833160 | 0.76 | RET (0.38) | KDM4E | |
| SCHEMBL4395555 | 0.76 | RAB9A (0.40) | MEN1KMT2AALDH1A1HCAR2KDM4E | |
| SCHEMBL4395549 | 0.76 | RAB9A (0.40) | MEN1KMT2AALDH1A1HCAR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089018-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| CN-101252935-A | Pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions containing them, and methods of their use | LEXICON GENETICS INC (US) | 2008-08-27 | — | — | CN | disclosed |
| WO-2008067121-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | LEXICON PHARMACEUTICALS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2006124897-A2 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITION | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | disclosed |