Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317502 | 0.85 | ALOX15 (0.50) | ALOX15ALDH1A1HPGDHSD17B10AKR1B1 | |
| SCHEMBL28822491 | 0.81 | PIK3CG (0.34) | ALOX15ALDH1A1HPGDHSD17B10PIK3CG | |
| SCHEMBL5564401 | 0.74 | KDM4E (0.56) | ALOX15ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL316631 | 0.72 | PIK3CG (0.44) | PIK3CGEGFR | |
| SCHEMBL316630 | 0.72 | PIK3CG (0.37) | PIK3CGEGFR | |
| SCHEMBL9903399 | 0.71 | ALDH1A1 (0.47) | ALOX15ALDH1A1HPGDHSD17B10AKR1B1 | |
| Purine SCHEMBL10946421 | 0.71 | ALDH1A1 (0.61) | ALOX15ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL6260367 | 0.70 | ALOX15 (0.50) | ALOX15ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL11769997 | 0.70 | ALDH1A1 (0.65) | ALOX15ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL3292267 | 0.70 | PIK3CG (0.47) | ALDH1A1HSD17B10PIK3CGTSHREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102210-A2 | COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | Vertex Pharmceuticals Incorporated (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076392-A2 | COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-06-26 | — | — | WO | disclosed |