Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.42 |
| ▸ | CDK2 | P24941 | 6/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | CDK4 | P11802 | 4/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.42 |
| ▸ | CCND1 | P24385 | 4/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37808 | 0.88 | RNASEH1 (0.45) | PDE5ACCNE2CCNE1CDK2CCNB2 | |
| SCHEMBL38486 | 0.83 | PDE5A (0.60) | PDE5ACCNE2CCNE1CDK2CCNB2 | |
| SCHEMBL3492213 | 0.76 | PDE5A (0.60) | PDE5ACCNE2CCNE1CDK2CCNB2 | |
| SCHEMBL3492352 | 0.76 | PDE5A (0.69) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL43869 | 0.76 | PDE5A (0.52) | PDE5ACCNE2CCNE1CDK2CCNB2 | |
| SCHEMBL37776 | 0.75 | PDE5A (0.61) | PDE5ACCNE2CCNE1CDK2CCNB2 | |
| SCHEMBL3492211 | 0.75 | PDE5A (0.67) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL37886 | 0.75 | PDE5A (0.59) | PDE5ACCNE2CCNE1CDK2CCNB2 | |
| SCHEMBL16175769 | 0.74 | PDE5A (0.63) | PDE5ACCNE2CCNE1CDK2CCNB2 | |
| SCHEMBL4518642 | 0.72 | PIP4K2A (0.66) | PDE5ACCNE2CCNE1CDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |