Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.59 |
| ▸ | ITGAV | P06756 | 16/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.59 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793131 | 0.90 | ITGB3 (0.59) | ITGB3ITGAVITGA2BCASRITGB1 | |
| SCHEMBL6797778 | 0.85 | ITGB3 (0.55) | ITGB3ITGAVITGA2BCASRITGB5 | |
| SCHEMBL6797331 | 0.85 | ITGB3 (0.58) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL383017 | 0.84 | ITGB3 (0.70) | ITGB3ITGAVITGA2B | |
| SCHEMBL7658323 | 0.83 | JAK2 (0.41) | ITGB3ITGAVITGA2BSMYD3 | |
| SCHEMBL383174 | 0.83 | ITGB3 (0.73) | ITGB3ITGAVITGA2BCASRITGB1 | |
| SCHEMBL382506 | 0.81 | ITGB3 (0.55) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL384017 | 0.81 | ITGB3 (0.56) | ITGB3ITGAVITGA2B | |
| SCHEMBL382964 | 0.81 | CASR (0.45) | ITGB3ITGAVITGA2BSMYD3CASR | |
| SCHEMBL6793124 | 0.81 | ITGB3 (0.71) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | claimed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |