Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 7/20 | 0.44 |
| ▸ | DRD3 | P35462 | 7/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGAV | P06756 | 2/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464438 | 0.89 | DRD2 (0.42) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL6796559 | 0.89 | CASR (0.45) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL382117 | 0.85 | DRD2 (0.44) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL27472952 | 0.85 | ITGB3 (0.42) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL382678 | 0.85 | ITGB3 (0.44) | ITGB3ITGAVITGA2BEPHX2 | |
| SCHEMBL27457825 | 0.83 | ITGB3 (0.39) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL27476108 | 0.83 | ITGB3 (0.39) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL6796240 | 0.83 | DRD2 (0.43) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL6800173 | 0.83 | CASR (0.43) | CASRDRD2DRD3ITGB3ITGAV | |
| SCHEMBL7651659 | 0.83 | RAB9A (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | claimed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| CN-1303377-A | Amino piperidine derivatives as integrin alpha beta 3 antagonists | MEIJI SEIKA KAISHA (JP) | 2001-07-11 | — | — | CN | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |