Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800282 | 0.87 | ALDH1A1 (0.42) | HDAC6HDAC1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1800409 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL1798621 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL1798607 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPTL3MBTL1MEN1LMNA | |
| SCHEMBL13425381 | 0.78 | FAAH (0.40) | ALDH1A1MAPTL3MBTL1KDM4ETSHR | |
| SCHEMBL20641176 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTL3MBTL1KDM4EMEN1 | |
| SCHEMBL1753870 | 0.77 | HDAC6 (0.58) | HDAC6HDAC1LMNAPKMHDAC3 | |
| SCHEMBL3326164 | 0.76 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL17766318 | 0.76 | TSHR (0.48) | HDAC6HDAC1ALDH1A1LMNAPKM | |
| SCHEMBL11050378 | 0.74 | HDAC6 (0.56) | HDAC6HDAC1ALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |