Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3833202 | 1.00 | PTGS2 (0.44) | PTGS2RECQLSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13832855 | 0.86 | ENPP3 (0.44) | PTGS2ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL1752242 | 0.81 | TDP1 (0.45) | PTGS2RECQLALDH1A1LMNATDP1 | |
| SCHEMBL1752243 | 0.81 | TDP1 (0.45) | PTGS2RECQLALDH1A1LMNATDP1 | |
| SCHEMBL9514535 | 0.81 | SMN1; SMN2 (0.43) | PTGS2SMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL9514545 | 0.81 | SMN1; SMN2 (0.43) | PTGS2SMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL19192912 | 0.80 | RECQL (0.45) | PTGS2RECQLSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9851108 | 0.79 | CYP1A2 (0.41) | PTGS2RECQLSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8952094 | 0.79 | ALDH1A1 (0.44) | RECQLSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL3132151 | 0.79 | KMT2A (0.43) | RECQLSMN1; SMN2ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102168-A1 | ACYLAMINOPYRAZOLES FOR TREATING CARDIOVASCULAR DISEASES | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008046527-A1 | ACYLAMINOPYRAZOLES FOR TREATING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-04-24 | — | — | WO | disclosed |