Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 11/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383252 | 1.00 | CASR (0.42) | CASRITGB3ITGAVITGA2BKDM4E | |
| SCHEMBL383158 | 0.95 | ITGB3 (0.44) | CASRITGB3ITGAVITGA2BKDM4E | |
| SCHEMBL6501575 | 0.89 | ITGB3 (0.40) | ITGB3ITGAVITGA2BKDM4EHTT | |
| SCHEMBL6496599 | 0.89 | ITGB3 (0.40) | ITGB3ITGAVITGA2BKDM4EHTT | |
| SCHEMBL6499244 | 0.88 | CNR1 (0.38) | ITGB3ITGAVITGA2BKDM4EHTT | |
| SCHEMBL383095 | 0.87 | ITGB3 (0.46) | ITGB3ITGAVITGA2BMCHR1 | |
| SCHEMBL382456 | 0.86 | ITGB3 (0.47) | ITGB3ITGAVITGA2BMCHR1ALDH1A1 | |
| SCHEMBL6500429 | 0.86 | ITGB3 (0.36) | ITGB3ITGAVITGA2BKDM4EHTT | |
| SCHEMBL6497814 | 0.86 | ITGB3 (0.41) | ITGB3ITGAVITGA2BKDM4EHTT | |
| SCHEMBL6498409 | 0.86 | DRD2 (0.38) | ITGB3ITGAVITGA2BMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |