Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835080 | 0.80 | AURKA (0.31) | AURKA | |
| SCHEMBL3834979 | 0.74 | KDR (0.34) | AURKA | |
| SCHEMBL3836136 | 0.74 | PARP1 (0.31) | — | |
| SCHEMBL3835834 | 0.73 | PTGS1 (0.35) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3836996 | 0.72 | AURKA (0.36) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3835742 | 0.71 | AURKA (0.37) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3840001 | 0.69 | PARP10 (0.36) | AURKA | |
| SCHEMBL3835512 | 0.69 | KDR (0.41) | AURKA | |
| SCHEMBL3839946 | 0.69 | AURKA (0.34) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3839735 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |