Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834573 | 0.73 | PIK3CD (0.31) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3835796 | 0.71 | MAP3K9 (0.38) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3835742 | 0.69 | AURKA (0.37) | KDRPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL3840001 | 0.67 | PARP10 (0.36) | KDRAURKAPARP1 | |
| SCHEMBL3835512 | 0.67 | KDR (0.41) | KDRAURKAPARP1 | |
| SCHEMBL3839735 | 0.66 | — | — | |
| SCHEMBL31158957 | 0.66 | GRM5 (0.37) | KDRPIK3CDPIK3CAPIK3CBAURKA | |
| SCHEMBL3836901 | 0.66 | GRM5 (0.37) | KDRPIK3CDPIK3CAPIK3CBAURKA | |
| SCHEMBL3836782 | 0.65 | AURKA (0.31) | KDRAURKA | |
| SCHEMBL3834548 | 0.64 | NAMPT (0.39) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |