Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639768 | 0.92 | MAPT (0.47) | RORCKDM4ELMNAMEN1KMT2A | |
| SCHEMBL3837011 | 0.91 | NR1H4 (0.49) | RORCKDM4ELMNAMEN1KMT2A | |
| SCHEMBL2638078 | 0.91 | LMNA (0.51) | RORCKDM4ELMNAMEN1KMT2A | |
| SCHEMBL2639066 | 0.90 | MEN1 (0.49) | RORCKDM4ELMNAMEN1KMT2A | |
| SCHEMBL2640022 | 0.90 | RORC (0.46) | RORCLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL3218393 | 0.88 | RORC (0.43) | RORCLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL3837731 | 0.88 | POLB (0.41) | RORCKDM4EMEN1KMT2AMRGPRX4 | |
| SCHEMBL3836027 | 0.88 | RORC (0.43) | RORCLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2638287 | 0.87 | RORC (0.44) | RORCKDM4ELMNAMEN1KMT2A | |
| SCHEMBL2639012 | 0.87 | RORC (0.46) | RORCLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742908-B1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | EP | claimed |