Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
| ▸ | TUBB | P07437 | 2/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839247 | 0.88 | PPARG (0.35) | PPARGPTGS1PTGS2ALDH1A1NPSR1 | |
| SCHEMBL3840372 | 0.86 | PPARG (0.35) | PPARGPTGS1PTGS2ALDH1A1NPSR1 | |
| SCHEMBL3839475 | 0.81 | TUBB4A (0.46) | PPARGTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3839514 | 0.80 | TUBB4A (0.36) | PPARGTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3837549 | 0.77 | TUBB4A (0.38) | PPARGTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3835082 | 0.73 | HTR2A (0.39) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3839592 | 0.70 | TUBB4A (0.39) | PPARGTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4153660 | 0.69 | ALDH1A1 (0.43) | ALDH1A1HTTMAPTKDM4EGAA | |
| SCHEMBL2346704 | 0.68 | POLB (0.44) | PTGS1PTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL2342932 | 0.68 | POLB (0.46) | PTGS1PTGS2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791537-B1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2009-10-14 | — | — | EP | claimed |