Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706998 | 0.83 | NPSR1 (0.45) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL5706996 | 0.83 | NPSR1 (0.45) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL20778292 | 0.81 | MAPT (0.38) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL29134126 | 0.81 | MAPT (0.38) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL19168953 | 0.75 | ALDH1A1 (0.48) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL7240646 | 0.74 | TDP1 (0.41) | TDP1 | |
| SCHEMBL1178944 | 0.74 | MGAM (0.44) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL28622235 | 0.70 | APOBEC3A (0.51) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL26325159 | 0.70 | APOBEC3A (0.51) | MAPTNPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL18590176 | 0.69 | MAPT (0.46) | MAPTNPSR1GLO1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |
| US-6020357-A | CARDIOVASCULAR DISORDERS; ANTCOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-01 | — | — | US | disclosed |