Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640680 | 0.91 | RXFP1 (0.45) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL1639052 | 0.91 | RXFP1 (0.40) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL27756536 | 0.86 | RXFP1 (0.44) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL3834758 | 0.86 | RXFP1 (0.41) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL1639088 | 0.80 | RXFP1 (0.44) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL1640694 | 0.80 | RAB9A (0.44) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL27777483 | 0.79 | RXFP1 (0.43) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL27777360 | 0.78 | HTR3A (0.47) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL14273359 | 0.74 | RXFP1 (0.42) | RXFP1TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL1639104 | 0.72 | P2RY12 (0.48) | RXFP1TP53MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094272-A2 | NITROGEN CONTAINING SUBSTITUTED HETEROCYCLES AS PLATELET ADP RECEPTOR INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008036843-A2 | NITROGEN CONTAINING SUBSTITUTED HETEROCYCLES AS PLATELET ADP RECEPTOR INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |