Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | STAT5B | P51692 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837214 | 0.87 | HTR2A (0.38) | KMT2AMEN1ALDH1A1HTR2AHTR2C | |
| SCHEMBL3839948 | 0.80 | KMT2A (0.41) | KMT2AMEN1ALDH1A1KDM4EHSD11B1 | |
| SCHEMBL1511696 | 0.76 | F2 (0.37) | CCR5KMT2AALDH1A1F2HSD11B1 | |
| SCHEMBL15219222 | 0.74 | CCR5 (0.40) | CCR5KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL28034923 | 0.74 | HSD11B1 (0.56) | CCR5KMT2AALDH1A1KDM4EF2 | |
| SCHEMBL6980390 | 0.72 | CTSD (0.53) | HSD11B1 | |
| SCHEMBL26413544 | 0.72 | HSD11B1 (0.45) | CCR5KMT2AALDH1A1F2HSD11B1 | |
| SCHEMBL925152 | 0.71 | NPSR1 (0.47) | CCR5KMT2AMEN1HSD11B1 | |
| SCHEMBL857496 | 0.71 | HSD17B10 (0.42) | KMT2AMEN1ALDH1A1KDM4EPOLB | |
| SCHEMBL26413513 | 0.71 | HSD11B1 (0.44) | CCR5KMT2AALDH1A1F2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111402-A2 | AMINOPYRAZOLE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008086128-A2 | AMINOPYRAZOLE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-17 | — | — | WO | disclosed |