Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5580019 | 0.79 | DCPS (0.43) | KDM4ECYP3A4MAPTSMN1; SMN2PDPK1 | |
| Hydrochloric Acid SCHEMBL7215707 | 0.78 | MAOA (0.41) | KDM4ECYP3A4MAPTSMN1; SMN2PDPK1 | |
| SCHEMBL7215765 | 0.74 | NPY5R (0.47) | KDM4ECYP3A4SMN1; SMN2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL7215863 | 0.73 | PDE5A (0.47) | KDM4ECYP3A4SMN1; SMN2ALOX15CYP2D6 | |
| Hydrochloric Acid SCHEMBL7215566 | 0.71 | GALR3 (0.52) | KDM4EMAPTSMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL7216215 | 0.71 | RAD52 (0.52) | KDM4ECYP3A4MAPTSMN1; SMN2CYP2D6 | |
| SCHEMBL18107153 | 0.70 | TLR8 (0.41) | KDM4ECYP3A4SMN1; SMN2PARP1JAK2 | |
| SCHEMBL311169 | 0.69 | JAK2 (0.41) | KDM4EMAPTSMN1; SMN2PDPK1CA12 | |
| Hydrochloric Acid SCHEMBL9037659 | 0.68 | JAK2 (0.41) | KDM4EMAPTSMN1; SMN2PDPK1CA12 | |
| SCHEMBL2252074 | 0.64 | ADORA2A (0.47) | KDM4ECYP3A4MAPTJAK2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104675-A1 | SUBSTITUTED 5H-PYRIMIDOL[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | The Medicines Company (Leipzig) GmbH (DE) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008077631-A1 | SUBSTITUTED 5H-PYRIMIDOL[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2008-07-03 | — | — | WO | disclosed |