Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7215863 | 0.98 | PDE5A (0.47) | NPY5RABCG2CLK4DAPK3MAP4K4 | |
| SCHEMBL7221486 | 0.87 | EGFR (0.54) | ABCG2EGFRAURKB | |
| Hydrochloric Acid SCHEMBL7215768 | 0.86 | EGFR (0.53) | ABCG2EGFRAURKB | |
| SCHEMBL7216215 | 0.78 | RAD52 (0.52) | CLK4EGFRMEN1KMT2APDE5A | |
| SCHEMBL7216427 | 0.76 | NPY5R (0.47) | NPY5RABCG2CLK4DAPK3MAP4K4 | |
| Hydrochloric Acid SCHEMBL7215566 | 0.75 | GALR3 (0.52) | EGFRDYRK1AMEN1KMT2AALDH1A1 | |
| SCHEMBL3836611 | 0.74 | KDM4E (0.42) | MEN1KMT2AALDH1A1LMNACYP3A4 | |
| SCHEMBL5580019 | 0.74 | DCPS (0.43) | KMT2AALDH1A1LMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7215707 | 0.73 | MAOA (0.41) | MEN1KMT2AALDH1A1LMNACYP3A4 | |
| SCHEMBL725815 | 0.70 | POLB (0.42) | ABCG2CLK4DAPK3MAP4K4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |