Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10476961 | 0.94 | APP (0.48) | APPFFAR1MAPTKDM4EMEN1 | |
| SCHEMBL3714277 | 0.91 | APP (0.55) | APPFFAR1MAPTKDM4EMEN1 | |
| SCHEMBL10091187 | 0.82 | ESR2 (0.53) | APPFFAR1MAPTKDM4EMEN1 | |
| SCHEMBL21511005 | 0.82 | APP (0.44) | APPFFAR1MAPTKDM4EMEN1 | |
| SCHEMBL12273056 | 0.82 | SLC18A3 (0.68) | APPFFAR1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL12279415 | 0.82 | DRD2 (0.56) | SLC18A3SIGMAR1 | |
| SCHEMBL12902344 | 0.80 | GRM5 (0.49) | SLC18A3SIGMAR1GRM5 | |
| SCHEMBL11025802 | 0.80 | NPY5R (0.39) | FFAR1MAPTKDM4EMEN1LMNA | |
| SCHEMBL12279471 | 0.80 | HTR3A (0.56) | SLC18A3SIGMAR1 | |
| SCHEMBL2050 | 0.79 | SLC18A3 (0.61) | SLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104669-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008070016-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2008-06-12 | — | — | WO | disclosed |