Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836795 | 0.81 | CYP1A2 (0.49) | SMN1; SMN2RAB9ANPC1KMT2AMAPT | |
| SCHEMBL3840526 | 0.73 | HSD17B10 (0.38) | KMT2AMEN1HTTALDH1A1HSD17B10 | |
| SCHEMBL3840992 | 0.70 | HSD17B10 (0.35) | HSD17B10KDM4ECYP1A2 | |
| SCHEMBL3839941 | 0.70 | KDM4E (0.38) | SMN1; SMN2RAB9ANPC1KMT2AMAPT | |
| SCHEMBL10366863 | 0.67 | KDM4E (0.37) | HSD17B10KDM4ECYP1A2 | |
| SCHEMBL3840588 | 0.63 | CYP1A2 (0.33) | HSD17B10CYP1A2 | |
| SCHEMBL12930257 | 0.62 | NPC1 (0.50) | SMN1; SMN2RAB9ANPC1KMT2AMAPT | |
| SCHEMBL3817059 | 0.62 | SLC22A6 (0.57) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL12930243 | 0.62 | NPC1 (0.57) | SMN1; SMN2RAB9ANPC1KMT2AMAPT | |
| SCHEMBL18203885 | 0.62 | P2RX7 (0.42) | KMT2AMAPTMEN1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833830-B1 | QUINOLINE DERIVATIVE, USE AND PRODUCTION THEREOF, AND DRUG CONTAINING THE SAME | BAYER SCHERING PHARMA AG (DE) | 2009-10-14 | — | — | EP | disclosed |
| EP-1833830-A1 | QUINOLINE DERIVATIVE, USE AND PRODUCTION THEREOF, AND DRUG CONTAINING THE SAME | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006066955-A1 | QUINOLINE DERIVATIVE, USE AND PRODUCTION THEREOF, AND DRUG CONTAINING THE SAME | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | disclosed |