SCHEMBL3837034

SCHEMBL3837034

COCc1nc(Br)c(Br)n1Cc1cc2c(cc1Cl)OCO2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.38
HSP90B1 P14625 3/20 0.38
TRAP1 Q12931 3/20 0.38
ALDH1A1 P00352 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 1/20 0.38
HPGD P15428 1/20 0.38
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
NPSR1 Q6W5P4 3/20 0.37
TSHR P16473 2/20 0.37
LMNA P02545 2/20 0.37
RAB9A P51151 1/20 0.37
HTT P42858 1/20 0.37
BRS3 P32247 4/20 0.36
EDNRA P25101 1/20 0.36
MAPT P10636 2/20 0.36
CYP1A2 P05177 3/20 0.34
CYP3A4 P08684 3/20 0.34
CYP2D6 P10635 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6160490 0.84 EDNRA (0.49) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL7503934 0.81 HSP90AA1 (0.41) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL3834423 0.80 HSP90AA1 (0.43) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL6159828 0.78 HSP90AA1 (0.39) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL3834411 0.76 HSP90AA1 (0.42) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL3836955 0.74 HSP90AA1 (0.38) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL7501751 0.74 ALDH1A1 (0.45) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL6582630 0.73 MEN1 (0.40) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL6164112 0.71 EDNRA (0.49) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2
SCHEMBL6577451 0.71 KDM4E (0.40) HSP90AA1HSP90B1TRAP1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861247-B1 NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS AVENTIS PHARMA SA (FR) 2009-10-07 EP disclosed
US-6143774-A DRUGS AS HYPOTENSIVE AGENTS HOECHST MARION ROUSSEL (FR) 2000-11-07 US disclosed
EP-0861247-A1 NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS HOECHST MARION ROUSSEL (FR) 1998-09-02 EP disclosed
WO-1997017339-A1 NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS HOECHST MARION ROUSSEL (FR) 1997-05-15 WO disclosed