SCHEMBL6164112

SCHEMBL6164112

CCCc1nc(Br)c(C=O)n1Cc1cc2c(cc1Cl)OCO2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 1/20 0.49
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HSP90AA1 P07900 5/20 0.37
HSP90B1 P14625 5/20 0.37
TRAP1 Q12931 5/20 0.37
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C19 P33261 2/20 0.33
CACNA1F O60840 1/20 0.32
CHRM1 P11229 1/20 0.32
ADRA1D P25100 1/20 0.32
HTR7 P34969 1/20 0.32
ADRA1A P35348 1/20 0.32
ADRA1B P35368 1/20 0.32
OPRM1 P35372 1/20 0.32
OPRD1 P41143 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6160490 0.86 EDNRA (0.49) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL7505827 0.84 HSP90AA1 (0.39) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL7499501 0.82 ALDH1A1 (0.43) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL6160770 0.81 HSP90AA1 (0.38) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL8416889 0.79 EDNRA (0.51) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL3838481 0.78 HSP90AA1 (0.37) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL7503964 0.78 EDNRA (0.63) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL6579996 0.77 HSP90AA1 (0.38) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL27462057 0.77 HSP90AA1 (0.39) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL3834411 0.77 HSP90AA1 (0.42) EDNRAKDM4EALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1549622-A1 SULFONYLBENZODIAZEPINONE ACETAMIDES AS BRADYKININ ANTAGONISTS Elian Pharmaceuticals Inc. (US) 2005-07-06 EP disclosed
EP-0863896-B1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS AVENTIS PHARMA SA (FR) 2005-02-09 EP disclosed
WO-2004033436-A1 SULFONYLBENZODIAZEPINONE ACETAMIDES AS BRADYKININ ANTAGONISTS ELAN PHARMACEUTICALS INC (US) 2004-04-22 WO disclosed
US-5986103-A IMIDAZOLE SUBSTITUTED BENZENE AND REDUCTION OF ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS HOECHST MARION ROUSSEL (FR) 1999-11-16 US disclosed
EP-0863896-A1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS HOECHST MARION ROUSSEL (FR) 1998-09-16 EP disclosed
WO-1997017340-A1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS HOECHST MARION ROUSSEL (FR) 1997-05-15 WO disclosed