SCHEMBL7501751

SCHEMBL7501751

CCCSc1nc(Br)c(Br)n1Cc1cc2c(cc1Cl)OCO2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
KDM4E B2RXH2 2/20 0.45
HPGD P15428 1/20 0.45
EDNRA P25101 1/20 0.39
MAPT P10636 3/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HSP90AA1 P07900 5/20 0.36
HSP90B1 P14625 5/20 0.36
TRAP1 Q12931 5/20 0.36
LMNA P02545 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7499501 0.87 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL6160490 0.80 EDNRA (0.49) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL7503934 0.79 HSP90AA1 (0.41) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL3834423 0.79 HSP90AA1 (0.43) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL6577451 0.78 KDM4E (0.40) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL6159828 0.76 HSP90AA1 (0.39) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL3834411 0.74 HSP90AA1 (0.42) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL3837034 0.74 HSP90AA1 (0.38) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL3836955 0.72 HSP90AA1 (0.38) ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA
SCHEMBL6582630 0.71 MEN1 (0.40) ALDH1A1SMN1; SMN2KDM4EHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0776325-B1 NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA SA (FR) 2002-11-20 EP disclosed
US-5932741-A TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS HOECHST MARION ROUSSEL (FR) 1999-08-03 US disclosed
US-5811444-A IMIDAZOLE DERIVATIVES ROUSSEL UCLAF (FR) 1998-09-22 US disclosed