Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.36 |
| ▸ | DLK1 | P80370 | 1/20 | 0.36 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839331 | 0.84 | KDR (0.32) | KDR | |
| SCHEMBL3837174 | 0.82 | KDR (0.34) | KDR | |
| SCHEMBL3837163 | 0.80 | KDR (0.35) | KDR | |
| SCHEMBL3836956 | 0.78 | SLC2A1 (0.35) | — | |
| SCHEMBL3836776 | 0.76 | AURKA (0.34) | KDRJAK3 | |
| SCHEMBL3835796 | 0.75 | MAP3K9 (0.38) | KDRMAP3K9MAP3K10MAP3K11FLT4 | |
| SCHEMBL3835406 | 0.75 | PARP1 (0.45) | JAK3 | |
| SCHEMBL3839251 | 0.73 | PARP1 (0.33) | — | |
| SCHEMBL3839267 | 0.72 | PIK3CD (0.32) | — | |
| SCHEMBL3834979 | 0.71 | KDR (0.34) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |