Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836958 | 0.89 | PARP1 (0.36) | PARP1ACHE | |
| SCHEMBL3835406 | 0.85 | PARP1 (0.45) | PARP1 | |
| SCHEMBL3837642 | 0.80 | PARP1 (0.37) | PARP1 | |
| SCHEMBL3837309 | 0.78 | PARP1 (0.40) | PARP1 | |
| SCHEMBL3836776 | 0.77 | AURKA (0.34) | — | |
| SCHEMBL3839331 | 0.77 | KDR (0.32) | — | |
| SCHEMBL3837343 | 0.75 | L3MBTL1 (0.39) | PARP1HTT | |
| SCHEMBL3836956 | 0.73 | SLC2A1 (0.35) | PARP1 | |
| SCHEMBL3835512 | 0.73 | KDR (0.41) | PARP1 | |
| SCHEMBL3834497 | 0.70 | PARP1 (0.47) | PARP1HRH3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |