Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907155 | 0.87 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KDM4EPKMLMNA | |
| SCHEMBL23467921 | 0.85 | ERCC1 (0.56) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EMAPT | |
| SCHEMBL3835071 | 0.81 | TSHR (0.47) | ALDH1A1SMN1; SMN2KDM4EPKMNPC1 | |
| SCHEMBL719800 | 0.78 | KDM4E (0.56) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EPKM | |
| SCHEMBL10255345 | 0.77 | KDM4E (0.54) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EPKM | |
| SCHEMBL1917603 | 0.77 | KDM4E (0.54) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EPKM | |
| SCHEMBL4676300 | 0.76 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EPKM | |
| SCHEMBL17941877 | 0.74 | CSNK2A2 (0.58) | ALDH1A1SMN1; SMN2L3MBTL1KDM4ELMNA | |
| SCHEMBL721162 | 0.74 | KDM4E (0.51) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EPKM | |
| SCHEMBL23574375 | 0.74 | KDM4E (0.60) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | disclosed |
| US-7091209-B2 | Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors | MERCK & CO., INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20040106627-A1 | Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECULARE P ANGELETTI SPA (IT) | 2004-06-03 | — | — | US | disclosed |
| EP-1309566-A1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002006246-A1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106627-A1 | Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors | DPYD, DUT, UMPS | ALDH1A1 23/4885SMN1; SMN2 3986/4885L3MBTL1 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.