Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249437 | 0.77 | EPHX1 (0.61) | AURKAHDAC1HDAC8TAAR1EPHX1 | |
| SCHEMBL611096 | 0.77 | MAOA (0.47) | HDAC1HDAC6TAAR1MPOPLAAT3 | |
| SCHEMBL30412030 | 0.76 | EPHX1 (0.59) | AURKAHDAC1HDAC8TAAR1EPHX1 | |
| SCHEMBL15008343 | 0.75 | MAPT (0.55) | HDAC1HDAC6MAPTRXFP1ALOX5 | |
| SCHEMBL15007832 | 0.75 | MAPT (0.55) | HDAC1HDAC6MAPTRXFP1ALOX5 | |
| SCHEMBL2762061 | 0.75 | MAPT (0.55) | HDAC1HDAC6MAPTRXFP1ALOX5 | |
| SCHEMBL2761735 | 0.75 | MAPT (0.55) | HDAC1HDAC6MAPTRXFP1ALOX5 | |
| SCHEMBL376652 | 0.75 | MAPT (0.55) | HDAC1HDAC6MAPTRXFP1ALOX5 | |
| SCHEMBL15007876 | 0.75 | MAPT (0.55) | HDAC1HDAC6MAPTRXFP1ALOX5 | |
| SCHEMBL4309679 | 0.73 | TAAR1 (0.60) | AURKAHDAC1HDAC8TAAR1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |