Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836958 | 0.85 | PARP1 (0.36) | PARP1 | |
| SCHEMBL3835406 | 0.85 | PARP1 (0.45) | PARP1 | |
| SCHEMBL3836776 | 0.80 | AURKA (0.34) | KDR | |
| SCHEMBL3837309 | 0.77 | PARP1 (0.40) | PARP1 | |
| SCHEMBL3839331 | 0.73 | KDR (0.32) | KDR | |
| SCHEMBL3835512 | 0.70 | KDR (0.41) | PARP1KDR | |
| SCHEMBL3835742 | 0.69 | AURKA (0.37) | KDR | |
| SCHEMBL3834497 | 0.68 | PARP1 (0.47) | PARP1SMN1; SMN2KDR | |
| SCHEMBL3840001 | 0.67 | PARP10 (0.36) | PARP1KDR | |
| SCHEMBL3834548 | 0.67 | NAMPT (0.39) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |