Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31687468 | 0.85 | ACKR3 (0.55) | IDO1AKT1ACKR3SIGMAR1 | |
| SCHEMBL16096578 | 0.82 | EPHX1 (0.40) | SLC6A2SLC6A4CKS1BSKP1SKP2 | |
| SCHEMBL30606540 | 0.79 | KDM4E (0.47) | IDO1OPRM1OPRK1 | |
| SCHEMBL26599282 | 0.79 | KDM4E (0.47) | IDO1OPRM1OPRK1 | |
| SCHEMBL20506777 | 0.77 | AKT1 (0.58) | IDO1AKT1CKS1BSKP1SKP2 | |
| SCHEMBL7834047 | 0.77 | DRD2 (0.47) | SLC6A2SLC6A4IDO1CKS1BSKP1 | |
| SCHEMBL4622655 | 0.76 | EPHX1 (0.44) | CKS1BSKP1SKP2 | |
| SCHEMBL22833183 | 0.76 | CTSL (0.54) | IDO1AKT1CKS1BSKP1SKP2 | |
| SCHEMBL1459336 | 0.76 | SIGMAR1 (0.55) | IDO1AKT1CKS1BSKP1SKP2 | |
| SCHEMBL7821922 | 0.75 | SLC6A2 (0.39) | SLC6A2SLC6A4IDO1CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111395-A1 | NEW PHENYL- (4-PHENYL-PYRIMIDIN-2-YL) - AMINES DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF ESSENTIALLY AS IKK INHIBITORS | Sanofi-Aventis (FR) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008099074-A1 | PHENYL- (4-PHENYL-PYRIMIDIN-2-YL) - AMINE DERIVATIVES AS IKK INHIBITORS, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | SANOFI-AVENTIS (FR) | 2008-08-21 | — | — | WO | disclosed |
| EP-1948704-A1 | PROCESS FOR THE MANUFACTURE OF FLUOROELASTOMERS HAVING BROMINE OR IODINE ATOM CURE SITES | DuPont Performance Elastomers L.L.C. (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-1904479-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | Sanofi-Aventis (FR) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007050933-A1 | PROCESS FOR THE MANUFACTURE OF FLUOROELASTOMERS HAVING BROMINE OR IODINE ATOM CURE SITES | DUPONT PERFORMANCE ELASTOMERS L.L.C. (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007006926-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2007-01-18 | — | — | WO | disclosed |