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SCHEMBL383850

SCHEMBL383850

CCCC[Si](C)(C)OC[C@H]1O[C@](n2ccc(N)nc2=O)(C(c2ccccc2)(c2ccccc2)c2ccc(OC)cc2)[C@@](F)(C(c2ccccc2)(c2ccccc2)c2ccc(OC)cc2)[C@@H]1O

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.31
▸ POLA1 P09884 1/20 0.31
▸ ST6GAL1 P15907 1/20 0.30
▸ TYMP P19971 1/20 0.30
▸ PDE4D Q08499 1/20 0.30
▸ PDE3A Q14432 1/20 0.30
▸ SLC29A1 Q99808 1/20 0.30
▸ BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL384130 0.87 PDE4D (0.39) POLA1TYMPPDE4DPDE3ASLC29A1
SCHEMBL3793142 0.76 PDE4D (0.37) TYMPPDE4DPDE3ASLC29A1BACE1
SCHEMBL3789736 0.72 NT5E (0.31) ST6GAL1TYMP
SCHEMBL9083312 0.71 PDE3A (0.39) L3MBTL1POLA1ST6GAL1PDE4DPDE3A
SCHEMBL23648799 0.70 PDE3A (0.36) TYMPPDE4DPDE3ASLC29A1
SCHEMBL383885 0.69 PDE4D (0.44) L3MBTL1POLA1ST6GAL1TYMPPDE4D
SCHEMBL1739169 0.69 PDE3A (0.32) TYMPPDE4DPDE3ASLC29A1
SCHEMBL30514382 0.68 TYMP (0.42) ST6GAL1TYMPBACE1
SCHEMBL5201335 0.67 TYMP (0.42) ST6GAL1TYMPBACE1
SCHEMBL383849 0.66 L3MBTL1 (0.40) L3MBTL1ST6GAL1TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408306-A1 SUBSTITUTED NUCLEOSIDE AND NUCLEOTIDE ANALOGS Alios Biopharma, Inc. (US) 2012-01-25 — — EP disclosed
WO-2010108140-A1 SUBSTITUTED NUCLEOSIDE AND NUCLEOTIDE ANALOGS ALIOS BIOPHARMA, INC. (US) 2010-09-23 — — WO disclosed