Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838690 | 1.00 | HTR2A (0.61) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3838687 | 1.00 | HTR2A (0.61) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6007356 | 0.92 | HTR2A (0.61) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6009245 | 0.88 | MGLL (0.54) | HTR2AHTR2CLMNA | |
| SCHEMBL3839897 | 0.87 | SLC18A3 (0.59) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3839900 | 0.87 | SLC18A3 (0.59) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3839903 | 0.87 | SLC18A3 (0.59) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6007451 | 0.85 | MEN1 (0.57) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6007922 | 0.85 | SLC18A3 (0.57) | HTR2ASMN1; SMN2LMNASLC18A3 | |
| SCHEMBL6007909 | 0.84 | MGLL (0.54) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078537-B2 | Phenylalkyl diamine and amide analogs | SK CORPORATION (KR) | 2006-07-18 | — | — | US | claimed |
| EP-1303488-B1 | PIPERIDINE COMPOUNDS FOR USE AS CCR-3 INHIBITORS | NOVARTIS AG (CH) | 2009-11-04 | — | — | EP | disclosed |
| US-7078537-B2 | Phenylalkyl diamine and amide analogs | SK CORPORATION (KR) | 2006-07-18 | — | — | US | disclosed |
| US-6670379-B2 | Inflammatory or allergic conditions, asthma, inhibition of eosinophil activation, conjunctivitis; (1-((R2-Amino-3-pyridin-3-yl-propyl)-piperidin-4-yl)-(4-fluoro-phenyl) -methanone | NOVARTIS AG (CH) | 2003-12-30 | — | — | US | disclosed |
| EP-1303488-A1 | PIPERIDINE COMPOUNDS FOR USE AS CCR-3 INHIBITORS | Novartis AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002004420-A1 | PIPERIDINE COUMPOUNDS FOR USE AS CCR-3 INHIBITORS | NOVARTIS AG (CH) | 2002-01-17 | — | — | WO | disclosed |