Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834244 | 0.90 | MRGPRX4 (0.35) | MRGPRX4FFAR1KDM4ESLC6A2SLC6A4 | |
| SCHEMBL222798 | 0.89 | MRGPRX4 (0.46) | MRGPRX4KDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL223728 | 0.89 | FFAR1 (0.44) | MRGPRX4FFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3836799 | 0.82 | TP53 (0.40) | MRGPRX4FFAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3839020 | 0.81 | FFAR1 (0.40) | MRGPRX4FFAR1KDM4ESLC6A2SLC6A4 | |
| SCHEMBL224611 | 0.78 | TP53 (0.45) | FFAR1KDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL224876 | 0.78 | MEN1 (0.44) | MRGPRX4FFAR1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6358732 | 0.73 | ALDH1A1 (0.38) | HTR1AALDH1A1SMN1; SMN2MAPK14 | |
| SCHEMBL2103277 | 0.70 | TAAR1 (0.45) | KDM4ESMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL224383 | 0.68 | HRH3 (0.40) | FFAR1SLC6A4HTR1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094668-A2 | 4-IMIDAZOLINES AS TAAR'S LIGANDS | F. Hoffmann-Roche AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008074679-A2 | 4-IMIDAZOLINES AS TAAR'S LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-26 | — | — | WO | disclosed |